Colorectal cancer monoclonal antibodies market forecast to total revenues of US$5.2Bn by 2019

Colorectal cancer monoclonal antibodies market forecast to total revenues of US$5.
© companiesandmarkets.
2014-04-11 15:35:03 - Monoclonal Antibodies Market in Colorectal Cancer to 2019 - a new market research report on companiesandmarkets.
Monoclonal antibodies market for colorectal cancer to witness moderate growth, as late-stage pipeline remains weak. The market value for monoclonal antibodies (mAbs) in colorectal cancer treatment will experience a moderate increase from US$3.7 billion in 2012 to US$5.2 billion by 2019, at a Compound Annual Growth Rate (CAGR) of 5%.
This moderate growth is due to the slow rise of the prevalent population and weakness of the late-stage pipeline. Currently, there is only one mAb product in Phase III development for the treatment of colorectal cancer, named IMC-1121B.
The efficacy of this drug has not yet been proven in large-scale, placebo-controlled Phase III trials, which creates an element of uncertainty in terms of the outcome of these products.
weak late-stage pipeline is not expected to drive market growth to a significant extent during the forecast period.
The current metastatic colorectal cancer market is dominated by three mAbs— Avastin, Erbitux and Vectibix — which are far more efficacious than the targeted small molecule therapies also marketed for this setting. Therefore analysts believe there is a strong opportunity for the entry of new mAbs into the market, as long as they prove superior efficacy when compared to Avastin.
A product that can attain first-line status in the treatment of colorectal cancer, or even second-line status by displacing Erbitux and Vectibix, would have access to a considerable patient population and be able to generate a substantial amount of revenue. Furthermore, there are currently no approved mAbs in the early-stage setting for colorectal cancer, reflecting an additional opportunity for the development of new products.
There are currently three monoclonal Antibody (mAb) treatments approved for metastatic colorectal cancer with the purpose of extending the patient´s lifespan; Avastin, Erbitux and Vectibix. The current market leader is Avastin, which generated revenues of US$6.2 billion in 2012 across a number of oncology indications. While compelling late-stage candidates are absent from the current pipeline, the anticipated rise in total prevalence of colorectal cancer in the top eight markets may inspire further investment. Pricing patterns for mAbs are highly favorable in the US, the largest market for colorectal cancer, and patent expirations are not expected to have a substantial effect on any of the featured markets. As a result of this analysts believe the global market has the potential to grow to a value of US$5.5 billion by 2019.
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11.4.14 15:52, kommentieren


Sci-fi, gaming and campy movies collide at GnomeCon

› Liberty Co. Schools› Liberty School Year Calendar› Download school menus› FPCA website› Long Co.
UPDATED: April 11, 2014 8:28 a.m.
ALL THE FANBOYS and gamer girls will come out to play this weekend, when GnomeCon descends upon Savannah like a beneficent dragon.
Now in its third year, the locally-organized sci-fi, fantasy and gaming convention has grown formidable wings, hosting three days of role-playing and more the Coastal Georgia Center April 11-13. There will be more authors, artists, filmmakers and gaming industry poo-bahs than ever at this magical gathering of self-proclaimed geeks, who are encouraged to bring their costumes and card collections.
While Nikki Wulf’s cosplay masquerade contest will surely be a highlight, many come to GnomeCon to meet fellow fantasy fans and play European and miniature-based board games. Highly anticipated this year is “I Drank What?” which may sound like a frat house hobby but is really Empire Games’ darkly hilarious contest of wills inspired by everyone’s favorite scene from The Princess Bride.
In between rounds, gnomers can catch performances by comedian Phil Keeling and the Odd Lot Improv Troupe, hear what inspires bestselling fantasy writers Jody Lynn Nye and Bill Fawcett and shop the sci-fi book sale to benefit Live Oak Public Libraries. Angela Beasley’s Puppet People and craft projects will keep little gnome hands entertained.
Also on the docket is a panel and screening with writer/director Larry Blamire, the twisted mind behind the Lost Skeleton of Cadavra, Trail of the Screaming Forehead and other B-rate cult favorites. Blamire will screen his films Friday evening and host a Sunday panel with GnomeCon veteran Todd “Professor Fear” Hanson. Blamire spoke with Connect last week about Monsterpalooza, spoofing Ed Wood and turning his steampunk project into a tabletop game.
Larry Blamire: Oh yes, I've been into monsters since I was a kid! The Superman TV shows, all the Godzillas, King Kong and of course, all of the Ray Harryhausen movies [Earth vs. The Flying Saucers, the original Clash of the Titans].
Ray was the stop-motion king. Years later he gave his name as a presenter on Trail of the Screaming Forehead, which was a huge honor.
When it came time for me to make a movie, it was a spoof of those really low-budget ‘50s movies.
LB: Actually, It Came from Outer Space was on the higher end! That was a studio release. Put an independent like Plan 9 from Outer Space next to that and you can see what low-budget really means.
LB: Definitely. The ones we spoof in our movies are the lowest of 'em all. Cat-Women of the Moon and the like. And of course, any Ed Wood movie.
LB: First of all, we have a great ensemble. I use the same actors in all my movies, so we're kind of like a family. And we have great designers who are into that classic look.
The last film we did was A Dark and Stormy Night, which was based on those 1930’s murder mysteries. We shot entirely on a soundstage, and production designer Anthony Tremblay came up with this incredible 1930s mansion set. Of course for the exterior shots, we use a small model, just like in the originals.
CS: Your ensemble includes your lovely wife, the actress Jennifer Blaire.
LB: It's terrific to work with Jen! And she's got such a great look, straight out of Cat-Women from the Moon.
The role she’s most famous for is Animala, who appears in The Lost Skeleton of Cadavra and The Lost Skeleton Returns Again. We’ll be shooting a third one later this year hopefully call The Lost Skeleton Walks Among Us.
CS: You also have a steampunk project in the works.
LB: Steam Wars completely different from the movie spoofs. It's a steampunk/sci-fi action adventure set in the year 1897 where warfare is fought with these machine warriors. You know how in WWII movies you follow a battalion or a tank and really get to know the crew? Well, it's like that except with these giant machines.
It’s a very visual concept. I’ve done a bunch of paintings around the concept, and last year Geek magazine published some of them with an article about Steam Wars. I’ve now partnered with some people on it, and the first thing we want to do is a series of three graphic novels, which are just about complete. Those will hopefully lead to a giant, huge, epic motion picture project [laughs].
I’d also like to do a tabletop game like the kind they play at GnomeCon.
LB: We do go to a fair amount. We go to Monsterpalooza in L.A., which started up a few years ago and is getting bigger, and we've been to Wonderfest in Kentucky a few times.
We have a 3-year-old, which makes it a little harder to go convention-hopping. We’re also just so busy! There’s the third Lost Skeleton movie, and we’re also close to launching The Adventures of Big Dan Frater, an audiobook that’s like an old time radio show using the characters from Trail of the Screaming Forehead.
LB: Well, he's not quite ready for those. But he does love Ultraman, which is this Japanese TV show from the '60s with monsters. And he likes Scooby-Doo.
LB: I've heard that, too. I have no idea how to go about such a thing, but I'm totally up for it.
Where: Coastal Georgia Center, 305 Fahm St.
Info: gnomecon.
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11.4.14 15:46, kommentieren